Pascal FAVREL

Professeur

PHARE

CAMPUS I, CAEN

pascal.favrel@unicaen.fr

+33 2 31 56 53 61

Thèmes de recherche

Mots clés : Mollusque, reproduction, Développement, génomique, peptidomique, RCPGs, Neuropeptides.

Développement de données d’expression (transcrits et neuropeptides) et d’outils de génomique fonctionnelle chez l’huître creuse Crassostrea gigas. Caractérisation de couples Récepteurs/ligands par endocrinologie/ Pharmacologie inverse. Etude des contrôles neuroendocriniens et paracrines de la reproduction et du développement chez les mollusques.

Enseignements et diffusions des connaissances

Enseignement de Biologie et Physiologie animales comparées (Licence de Sciences de la Vie, Master SVT), biologie cellulaire et moléculaire (Licence SV), endocrinologie évolutive et comparée, génomique et évolution (Master).

Responsabilités administratives

Directeur de la Structure Fédérative de Recherche ICORE (Interaction Cellule-Organisme-Environnement) de l’Université de Caen Basse-Normandie https://www.unicaen.fr/icore/
Coordinateur de l’ANR internationale NEMO » NEuropeptides of Marine Organisms » (ANR 14CE02 0020: 2014-2019) « Défi : Gestion sobre des ressources et adaptation au changement climatique »
Co-responsable du groupe de travail « Evolution, développement, biodiversité » du GDR 3606 REPRO: Approche intégrative et translationnelle de la reproduction animale et humaine.

Galerie d'images

Article dans une revue

2023

ref_biblio: Favrel, P., Dubos, M., Bernay, B., Pasquier, J., Schwartz, J., Lefranc, B., Mouret, L., Rivière, G., Leprince, J., & Bondon, A. (2023, Nov). Structural and functional characterization of an egg-laying hormone signaling system in a lophotrochozoan -- The pacific oyster (Crassostrea gigas). General and Comparative Endocrinology, 346, 114417. <10.1016/j.ygcen.2023.114417>. <hal-04317342>.

2021

ref_biblio: Le Franc, L., Bernay, B., Petton, B., Since, M., Favrel, P., & Rivière, G. (2021, Mar). A functional m 6 A-RNA methylation pathway in the oyster Crassostrea gigas assumes epitranscriptomic regulation of lophotrochozoan development. FEBS Journal, 288 (5), 1696-1711. <10.1111/febs.15500>. <hal-02952460>.

ref_biblio: Réalis-doyelle, E., Schwartz, J., Dubos, M.-P., & Favrel, P. (2021, May). Molecular and physiological characterization of a crustacean cardioactive signaling system in a lophotrochozoan -- the Pacific oyster ( Crassostrea gigas ): a role in reproduction and salinity acclimation. Journal of Experimental Biology, 224 (10). <10.1242/jeb.241588>. <hal-03241156>.

ref_biblio: Réalis-doyelle, E., Schwartz, J., Cabau, C., Le Franc, L., Bernay, B., Rivière, G., Klopp, C., & Favrel, P. (2021). Transcriptome Profiling of the Pacific Oyster Crassostrea gigas Visceral Ganglia over a Reproduction Cycle Identifies Novel Regulatory Peptides. Marine drugs, 19 (8), 452. <10.3390/md19080452>. <hal-03330324>.

ref_biblio: Schwartz, J., Réalis-doyelle, E., Le Franc, L., & Favrel, P. (2021, Aug). A Novel Dop2/Invertebrate-Type Dopamine Signaling System Potentially Mediates Stress, Female Reproduction, and Early Development in the Pacific Oyster (Crassostrea gigas). Marine Biotechnology. <10.1007/s10126-021-10052-5>. <hal-03327466>.

2019

ref_biblio: Cherif-feildel, M., Berthelin, C.H., Rivière, G., Favrel, P., & Kellner, K. (2019, Feb). Data for evolutive analysis of insulin related peptides in bilaterian species. Data in Brief, 22, 546-550. <10.1016/j.dib.2018.12.050>. <hal-02143349>.

ref_biblio: Cherif-feildel, M., Heude Berthelin, C., Adeline, B., Favrel, P., Kellner, K., & Rivière, G. (2019, Jan). Molecular evolution and functional characterisation of insulin related peptides in molluscs: Contributions of Crassostrea gigas genomic and transcriptomic-wide screening. General and Comparative Endocrinology, 271, 15-29. <10.1016/j.ygcen.2018.10.019>. <hal-02142617>.

ref_biblio: Schwartz, J., Réalis-doyelle, E., Dubos, M.-P., Lefranc, B., Leprince, J., & Favrel, P. (2019, Jun). Characterization of an evolutionarily conserved calcitonin signaling system in a lophotrochozoan, the Pacific oyster ( Crassostrea gigas ). Journal of Experimental Biology, jeb.201319. <10.1242/jeb.201319>. <hal-02174652>.

2018

ref_biblio: Dubos, M.-P., Zels, S., Schwartz, J., Pasquier, J., Schoofs, L., & Favrel, P. (2018, May). Characterization of a tachykinin signalling system in the bivalve mollusc Crassostrea gigas. General and Comparative Endocrinology. <10.1016/j.ygcen.2018.05.003>. <hal-01838268>.

ref_biblio: Schwartz, J., Dubos, M.-P., Pasquier, J., Zatylny-gaudin, C., & Favrel, P. (2018, Dec). Emergence of a cholecystokinin/sulfakinin signalling system in Lophotrochozoa. Scientific Reports, 8 (1), 16424. <10.1038/s41598-018-34700-4>. <hal-01927201>.

2017

ref_biblio: Dubos, M.-P., Bernay, B., & Favrel, P. (2017, Mar). Molecular characterization of an adipokinetic hormone-related neuropeptide (AKH) from a mollusk. General and Comparative Endocrinology, 243, 15-21. <10.1016/j.ygcen.2016.11.002>. <hal-02153949>.

ref_biblio: Rivière, G., He, Y., Tecchio, S., Crowell, E., Gras, M., Sourdaine, P., Guo, X., & Favrel, P. (2017, Jun). Dynamics of DNA methylomes underlie oyster development. PLoS Genetics, 13 (6), e1006807. <10.1371/journal.pgen.1006807>. <hal-02153935>.

2015

ref_biblio: Riviere, G., Klopp, C., Ibouniyamine, N., Huvet, A., Boudry, P., & Favrel, P. (2015, Dec). GigaTON: an extensive publicly searchable database providing a new reference transcriptome in the pacific oyster Crassostrea gigas. BMC Bioinformatics, 16, 401. <10.1186/s12859-015-0833-4>. <hal-01258440>.

2014

ref_biblio: Bigot, L., Beets, I., Dubos, M.-P., Boudry, P., Schoofs, L., & Favrel, P. (2014). Functional characterization of a short neuropeptide F-related receptor in a lophotrochozoan, the mollusk Crassostrea gigas. Journal of Experimental Biology, 217 (16), 2974--2982. <10.1242/jeb.104067>. <hal-02548665>.

ref_biblio: Dheilly, N.M., Jouaux, A., Boudry, P., Favrel, P., & Lelong, C. (2014, Nov). Transcriptomic Profiling of Gametogenesis in Triploid Pacific Oysters Crassostrea gigas: Towards an Understanding of Partial Sterility Associated with Triploidy. PLoS ONE, 9 (11), e112094. <10.1371/journal.pone.0112094>. <hal-01345129>.

ref_biblio: Zatylny-gaudin, C., & Favrel, P. (2014, Oct). Diversity of the RFamide Peptide Family in Mollusks. Frontiers in Endocrinology, 5. <10.3389/fendo.2014.00178>. <hal-02154046>.

2012

ref_biblio: Bigot, L., Zatylny-gaudin, C., Rodet, F., Bernay, B., Boudry, P., & Favrel, P. (2012, Apr). Characterization of GnRH-related peptides from the Pacific oyster Crassostrea gigas.. Peptides, 34 (2), 303-10. <10.1016/j.peptides.2012.01.017>. <hal-00788233>.

2009

ref_biblio: Fleury, E., Huvet, A., Lelong, C., De Lorgeril, J., Boulo, V., Gueguen, Y., Bachère, E., Tanguy, A., Moraga, D., Fabioux, C., Lindeque, P., Shaw, J., Reinhardt, R., Prunet, P., Davey, G., Lapegue, S., Sauvage, C., Corporeau, C., Moal, J., Gavory, F.F., Wincker, P., Moreews, F., Klopp, C., Mathieu, M., Boudry, P., & Favrel, P. (2009, Jul). Generation and analysis of a 29,745 unique Expressed Sequence Tags from the Pacific oyster (Crassostrea gigas) assembled into a publicly accessible database: the GigasDatabase. BMC Genomics, 10 (341), 341. <10.1186/1471-2164-10-341>. <inria-00435769>.

2005

ref_biblio: Le Gall, L., Lelong, C., Rusig, A.-M., & Favrel, P. (2005). Characterization of an actin gene family in \textlessi\textgreaterPalmaria palmata\textless/i\textgreater and \textlessi\textgreaterPorphyra purpurea\textless/i\textgreater (Rhodophyta). Cahiers de Biologie Marine, 46 (3), 311-322. <10.21411/CBM.A.A266AA9F>. <mnhn-03629652>.

2000

ref_biblio: Henry, J., Zatylny-gaudin, C., & Favrel, P. (2000). HPLC and electrospray ionization mass spectrometry as tools for the identification of APGWamide-related peptides in gastropod and bivalve mollusks: comparative activities on Mytilus muscles.. Brain Research. <hal-01991107>.